Upstream Bio, Inc. (UPB:NASDAQ) closed at $3.38 on October 14, 2026, down 4.79% on the day. The stock trades 90.0% below its 52-week high of $33.68 and 2.6% above its 52-week low of $3.30. Over the past year, it lost 82.2%. Upstream Bio, Inc. is part of the Health Care sector.
| 5D | 1M | 3M | 6M | 1Y |
|---|---|---|---|---|
| -24.47% | -38.90% | -50.90% | -64.46% | -82.23% |
In 252 trading sessions since October 13, 2025, UPB closed higher on 118 days (47%). Its best day was March 11, 2026 (+15.27%) and its worst was February 11, 2026 (-47.18%). The stock moved 10% or more in a single session 13 times.
Upstream Bio is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. We are developing verekitug, the only known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin ("TSLP"), a cytokine which is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune mediated diseases. Preclinical and clinical data to date demonstrate verekitug's highly potent inhibition of the TSLP receptor, which we believe will translate to a differentiated product profile, including improved clinical outcomes, substantially extended dosing intervals and the potential to treat a broad spectrum of patients.
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Based on end-of-day data. For information only, not investment advice.