INO More Than Triples as 25 U.S. Stocks Gain 20%+ (Nov 2, 2026)
Inovio Pharmaceuticals, Inc. (INO:NASDAQ) more than tripled on Monday, November 2, gaining 214% and topping the list of U.S. movers. 25 U.S. stocks gained 20% or more. In Canada, Homerun Resources Inc. (HMR:TSXV) topped the list with 22.7%. 5 of the 10 biggest U.S. gainers had a news headline in the last two days.
The Canadian board was far tamer than the U.S. one. Even HMR's 22.7% gain, to $0.46, would not have made the U.S. top ten, where GNTA took the tenth spot with 32.1%. Behind HMR came UCU at 17.2% ($2.39), OZ at 16.7% ($0.28), CWL at 16.5% ($1.34) and CCCM at 15.5% ($0.67). CWL was the lone TSX name in the group, while the rest traded on the TSXV. The Canadian sectors ranged across technology, mining, energy and diversified industries. The U.S. list leaned toward health care, with INO, INLF, NMRA and GNTA all in its top ten.
Stand-out moves
Inovio Pharmaceuticals, Inc. (INO:NASDAQ)
INO more than tripled, up 213.7%, to close at $1.89, on 43.3× its average daily volume. It was its biggest one-day gain since at least October 2025. The close is its highest since February 24, 2026. The stock now trades 66% above its 50-day average. Our Spikes scanner recorded a spike on Fri, May 08, 2026 at $1.79 with a volume of 21M+. On Fri, Oct 30, 2026, it hit a new 52-Week Low of $0.60. It appeared on our News Catalysts scanner in the 'BIOTECH' category.
VCI Global Limited (VCIG:NASDAQ)
VCIG more than doubled, up 168.4%, to close at $8.16, on 1.4× its average daily volume. It was its biggest one-day gain since at least October 2025. The close is its highest since July 23, 2026. The stock now trades 518% above its 50-day average. Our Spikes scanner recorded a spike on Wed, Oct 21, 2026 at $0.34 with a volume of 17M+. On Fri, Oct 30, 2026, it hit a new 52-Week Low of $0.17.
ClearOne, Inc. (CLRO:NASDAQ)
CLRO soared 65.7% to close at $5.65, on 9.1× its average daily volume. It was its biggest one-day gain since October 23, 2026. The stock now trades 30% above its 50-day average. Our Spikes scanner recorded a spike on Tue, Oct 27, 2026 at $6.23 with a volume of 26M+.
Top 10 U.S. gainers
| Ticker | Price | % Change | Volume | Latest headline |
|---|---|---|---|---|
| INO:NASDAQ | $1.89 | +213.75% | 220,169,477 | INOVIO Receives FDA Accelerated Approval for VOCERYQ to Reduce Surgery Frequency in Adults with RRP |
| VCIG:NASDAQ | $8.16 | +168.4% | 6,097,793 | No recent news |
| CLRO:NASDAQ | $5.65 | +65.69% | 38,934,771 | No recent news |
| INLF:NASDAQ | $0.290 | +56.7% | 436,086,347 | No recent news |
| EVGO:NASDAQ | $1.85 | +46.83% | 72,026,814 | EVgo's Q3 Report Tests Whether A Strong Charging Business Can Offset A Guidance Cut |
| SEGG:NASDAQ | $1.93 | +45.11% | 34,503,075 | SEGG Media Reports More Than 1,500% Year-Over-Year Revenue Growth in Second Quarter, Driven by Veloc... |
| HXHX:NASDAQ | $0.236 | +38.91% | 51,751,205 | Haoxin Holdings Limited Provides Shareholder Update Regarding Broker-Assisted Trading for HXHX Share... |
| IFBD:NASDAQ | $1.03 | +37.83% | 1,006,429 | No recent news |
| NMRA:NASDAQ | $0.496 | +34.99% | 5,722,443 | No recent news |
| GNTA:NASDAQ | $0.817 | +32.07% | 1,565,787 | Genenta Unveils Saentra Forge as Its New Brand, Advancing Its Transformation into a Strategic Indust... |
Headlines behind the moves
- EVGO (+46.8%): EVgo's Q3 Report Tests Whether A Strong Charging Business Can Offset A Guidance Cut
- SEGG (+45.1%): SEGG Media Reports More Than 1,500% Year-Over-Year Revenue Growth in Second Quarter, Driven by Veloce
- HXHX (+38.9%): Haoxin Holdings Limited Provides Shareholder Update Regarding Broker-Assisted Trading for HXHX Shares
- GNTA (+32.1%): Genenta Unveils Saentra Forge as Its New Brand, Advancing Its Transformation into a Strategic Industrial Platform
Top 10 U.S. losers
| Ticker | Price | % Change | Volume | Latest headline |
|---|---|---|---|---|
| KPTI:NASDAQ | $0.112 | -83.08% | 44,037,576 | Karyopharm, deep in debt, to sell itself in bankruptcy |
| DRUG:NASDAQ | $26.20 | -52.35% | 1,819,941 | Bright Minds Biosciences Faces Partial FDA Clinical Hold on BMB-101 Phase 2 Epilepsy Study |
| AIOK:NASDAQ | $12.63 | -47.75% | 2,171,435 | No recent news |
| JAGX:NASDAQ | $0.884 | -45.43% | 2,153,173 | CSO of Napo Pharmaceuticals, a Jaguar Health Family Company, and Clinical Investigators Evaluating C... |
| JDZG:NASDAQ | $0.526 | -43.77% | 3,979,007 | No recent news |
| MTEN:NASDAQ | $0.500 | -41.37% | 704,692 | No recent news |
| SVRN:NASDAQ | $17.78 | -40.22% | 253,730 | No recent news |
| MLEC:NASDAQ | $0.850 | -39.29% | 136,266 | No recent news |
| XMAX:NASDAQ | $4.01 | -37.49% | 4,469,085 | XMax Doubles Down on Nvidia to Dominate the AI Arms Race |
| OFRM:NYSE | $9.44 | -37.15% | 7,899,982 | Once Upon a Farm Recalls Tractor Wheels After Choking Reports Hit 18% of Sales |
Top Canadian gainers (TSX, TSXV, CSE)
| Ticker | Price | % Change | Volume | Latest headline |
|---|---|---|---|---|
| HMR:TSXV | $0.460 | +22.67% | 110,500 | No recent news |
| UCU:TSXV | $2.39 | +17.16% | 617,249 | Canadian Rare Earth Stocks With Up To 97% Fair Value Upside |
| OZ:TSXV | $0.280 | +16.67% | 878,750 | No recent news |
| CWL:TSX | $1.34 | +16.52% | 85,300 | No recent news |
| CCCM:TSXV | $0.670 | +15.52% | 391,467 | C3 Metals hits highest-grade copper-gold-silver mineralization yet at Peru Project |
| LFLR:CSE | $0.285 | +14% | 211,977 | No recent news |
| KUYA:CSE | $0.455 | +13.75% | 157,646 | No recent news |
Top Canadian losers (TSX, TSXV, CSE)
| Ticker | Price | % Change | Volume | Latest headline |
|---|---|---|---|---|
| DRUG:CSE | $36.98 | -51.97% | 2,013 | Bright Minds Biosciences Faces Partial FDA Clinical Hold on BMB-101 Phase 2 Epilepsy Study |
| RLYG:TSXV | $0.330 | -40% | 365,500 | No recent news |
| SGML:TSXV | $7.20 | -24.21% | 223,154 | Sigma Lithium extends debt maturities, reports 32% third-quarter gross margin |
| LUME:TSX | $14.52 | -19.24% | 26,366 | Why Marvell Stock Is Tumbling Today |
| EMO:TSXV | $0.220 | -18.52% | 569,921 | No recent news |
| PKT:TSXV | $6.30 | -18.5% | 14,736 | No recent news |
| BOGO:TSXV | $0.690 | -17.86% | 502,466 | No recent news |
| PALS:TSXV | $2.10 | -13.58% | 45,954 | No recent news |
| NDM:TSX | $0.970 | -13.39% | 732,808 | No recent news |
New 52-week highs and lows (U.S.)
New highs: BDL, REPL, LEGH, ZONE, EXPO, RYZ, HOG, MORN, VLTO, REGN
New lows: JAGX, JDZG, RCT, GCDT, HUBC, SHFS, ENHA, NXXT, OPNW, GNLN
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